Dr. Li Weihui, Professor, doctoral/master’s supervisor, postdoctoral co-supervisor

Contact

E-mail: lwhlbx@gxu.edu.cn

Biography

Li Weihui, professor, doctoral/master's supervisor, postdoctoral cooperation supervisor, Deputy Secretary of the Party Committee and deputy dean of scientific research of the College, Guangxi Jieqing, Guangxi Bagui Youth Top talent, National Institute of Education Administration, the third period of high level talent training class. In December 2013, he graduated from Huazhong Agricultural University, majoring in Microbiology, and obtained his doctorate degree. From January 2014 to January 2019, he worked as a postdoctoral researcher at the State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University. In February 2019, he was introduced to the College of Life Science and Technology of Guangxi University as a high-level talent. Academic leader and permanent member of the State Key Laboratory for Conservation and Utilization of Subtropical Agricultural Biological Resources; And Member of Guangxi Microbiology and Enzyme Engineering Technology Research Center. He has won the National Scientific Research Outstanding Achievement Award (Second prize in Natural Science, an important member), the Outstanding sponsor of China Postdoctoral Science Foundation, the Outstanding Postdoc, the outstanding doctoral dissertation of Hubei Province and the third Outstanding Academic Paper of Wuhan Natural Science and other awards and honors. Reviewer of international journals such as Nucleic Acids Research, Synthetic and Systems Biotechnology and Microbiology Spectrum, review expert of National Natural Science Foundation of China, review expert of China Postdoctoral Science Foundation, review expert of National Research Platform, expert of Guangxi, Jiangxi and Jiangsu Science and Technology Expert Database, etc. The achievements of Nucleic Acids have been published in internationally renowned journals such as Nat Commun (2 articles), Nucleic Acids Res (3 articles) and PLOS Pathog, etc. The average impact factor of the representative papers is 14.69. As the project host, he undertook 3 projects of National Natural Science Foundation, 1 sub-project of National Key Research and development Plan, Guangxi Outstanding Youth Science Foundation and many other provincial and ministerial level projects.

Main social part-time job

1. Member of the General Microbiology Committee of the Chinese Society of Microbiology;

2. Member of Tuberculosis Committee of Chinese Research Hospital Society;

3. Member of Scientific Research Committee of the 18th Committee of Tuberculosis Society of Chinese Medical Association;

4. Member of Academic Bridge Evaluation Expert Database of Talent Development Professional Committee of China Education Development Strategy Society;

5. Deputy editor of Genomics and Applied Biology;

6. Vice Chairman and Executive Director of Guangxi Society of Biochemistry and Molecular Biology;

7. Executive Director of Guangxi Society of Microbiology;

8. Mentor of Guangxi Baigui Youth Talent Program.

Scientific research projects undertaken

1. Subproject of National Key Research and Development Plan, 2020YFA0907200, 2020.11 ~ 2025.10, 1.38 million yuan, host;

2. Project of National Natural Science Foundation of China, 31870036,2019.01 ~ 2022.12, 610,000 yuan, hosted;

3. Guangxi Outstanding Youth Science Foundation Project, 2022JJG130005, 2023.06 ~ 2027.05, 400,000 yuan, hosted;

4. Guangxi Bagui Youth Top Talent Project, 2024.01 ~ 2026.12, 600,000 yuan, hosted;

5. Regional Project of National Natural Science Foundation of China, 32360013,2024.01 ~ 2027.12, 320,000 yuan, hosted;

6. Sub-project of Guangxi Science and Technology Major Project, 2023AA15013, 2023.11 ~ 2026.10, 312,000 yuan, hosted;

7. National Natural Science Foundation of China Youth Project, 31401108,2015.01 ~ 2017.12, 240,000 yuan, host;

8. State Key Laboratory for Conservation and Utilization of Subtropical Agricultural Biological Resources -- Special Project for Young Talents, SKLCUSA-a02, 202109 ~ 2022.09, 250,000 yuan, hosted;

9. Multiplication Plan of Natural Science and Technology Innovation and Development of Guangxi University - "Four Qing" Talent Cultivation Project (post-subsidy of the national "Four Qing" defense), 2023BZRC008, 2023.06 ~ 2024.06, 150,000 yuan, hosted;

10. National Talent Cultivation Project of Guangxi University, 2019.01 ~ 2021.12, 1.5 million yuan, host;

11. Research Start-up Project of Guangxi University, 2019.01 ~ 2021.12, 500,000 yuan, host;

12. Special Support from China Postdoctoral Science Foundation, 2016T90699, 2016.06-2018.06, 150,000 yuan, host;

13. First-level Project Funding of China Postdoctoral Science Foundation, 2014M560612, 2014.10 ~ 2016.10, 80,000 yuan, host;

14. Multiplication Plan of Natural Science and Technology Innovation and Development - "Top Paper" Cultivation Project (post-publication grant of Nature Communications), Guangxi University, 2024.06 ~ 2025.06, 100,000 yuan, host;

15. Key Cultivation Project of Graduate Education and Teaching Reform Multiplication Plan, Guangxi University, 2024P04, 2024.06 ~ 2025.06, 30,000 yuan, host.

Research direction:

1. The discovery of bacterial second messenger receptor and its function;

2. Microbial and drug targets;

3. Microbial infection and host immunity.

Awards and honors received:

1. Won the second prize of National Scientific Research Outstanding Achievement Award (Natural Science), an important member, 2013;

2. Won the outstanding doctoral dissertation of Hubei Province;

3. Won the 3rd Natural Science Excellent Academic Paper Award of Wuhan City;

4. Won the first Prize of Guangxi Higher Education Teaching Achievement, an important member, 2021;

5. Won the special Prize of Guangxi University Teaching Achievements, important member, 2021;

6. Excellent Head Teacher of Guangxi University (for three consecutive years), 2019-2020 academic year, 2020-2021 academic year, 2021-2022 academic year;

7. "Good Teacher in my Mind" of Guangxi University (three consecutive years), 2021, 2022, 2023;

8. Excellent Communist Party Member of Guangxi University, 2019-2021, 2021-2023;

9. Excellent Instructor of the 4th Guangxi College Students Creativity, Innovation and Entrepreneurship Competition, 2022.

Awarded for guiding students

1. As a primary PI, guided the students to win the Global Silver Award of the International Genetic Engineering Machine Competition (iGEM) (reported by People's Daily), twice in 2022 and 2023;

2. Guiding the GXU-China team to win the Furong Student-Academic Research Award, 2022;

3. Guided the students to win 1 third prize of Innovation and Entrepreneurship and 1 third prize of Scientific inquiry in the 8th National College Students Life Science Competition, 2023;

4. Guided students to win 1 second prize, 1 third prize and 1 second prize of scientific inquiry in Provincial College Students' Life Science Competition - Innovation and Entrepreneurship, 2023;

5. Guided students to win two second prizes in the Third Creative Entrepreneurship Innovation Competition of Undergraduate universities in Guangxi, 2021;

6. Guided students to win 2 first prizes and 2 third prizes of the Fourth Creative Entrepreneurship and Innovation Competition of Guangxi Undergraduate Universities, 2022;

7. Guided students to win 3 first prizes and 1 second prizes of the 5th Creative Entrepreneurship and Innovation Competition of Guangxi Undergraduate Universities, 2023;

8. Guided the students to win the excellent undergraduate graduation thesis of Guangxi University, 2022 (2), 2023 (2);

9. Guided the graduate students to win the first prize of the Academic Achievement Award of the First Graduate Academic and Cultural Festival of Guangxi University, 1 network popularity award, 1 excellent poster award, 2023;

10. As the head teacher, guided the undergraduate class to win the honors of 2019-2020 academic year, 2021-2022 academic year Advanced Class Group, 2019-2020 academic year May Fourth Red Flag League Branch, etc.

11. Guided the graduate students to participate in the academic annual meeting and won 5 first prizes and 3 second prizes;

12. Guided doctoral students, master students and undergraduates to win more than 10 national scholarships;

13. Guided the students to win the Guangxi Education Graduate Innovation Plan project, 1 doctoral student (30,000 yuan), 2 master students (10,000 yuan/item).

Representative Papers

1.Xiaocui Ling, Xiao Liu, Kun Wang, Minho Guo, Yanzhe Ou, Danting Li, Yulin Xiang, Jiachen Zheng, Lihua Hu, Honeybun Zhang, Meihui Li*. Lsr2 acts as a cyclic di-GMP receptor that promotes keto-mycolic acid synthesis and biofilm formation in mycobacteria. Nature Communications, 2024, 15:695, DOI: 10.1038/s41467-024-44774-6. (I2022F: 16.6, Journal of Nature Indices)

2.Weihui Li#, Tao Cui#, Lihua Hu#, Ziqing Wang, Zongqiang Li and Zheng-Guo He*. Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity. Nature Communications, 2015, 6:8330, DOI: 10.1038/ncomms9330. (IF2021: 17.694, Journal of Nature Index)

3.Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li, Tao Cui and Zheng-Guo He*. Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense. Nucleic Acids Research, 2018, 46 (14):7270-7283. (IF2021: 19.160, Top Journal)

4.Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen and Zheng-Guo He*. HpoR, a novel c-di-GMP effective transcription factor, links the second messenger's regulatory function to the mycobacterial antioxidant defense. Nucleic Acids Research, 2018, 46 (7):3595-3611. (I2021F: 19.160, Top Journal)

5.Weihui Li and Zheng-Guo He*. LtmA, a novel cyclic di-GMP-responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis. Nucleic Acids Research, 2012, 40 (22):11292-11307. (2021IF: 19.160, Top Journal)

6.Qingbin Hu, Jiaxun Zhang, Yu Chen, Lihua Hu, Weihui Li*, Zheng-Guo He*. Cyclic di-GMP co-activates the two-component transcriptional regulator DevR in Mycobacterium smegmatis in response to oxidative stress. Journal of Biological Chemistry, 2019, 294(34):12729-12742. (Journal of Nature Index, co-corresponding author)

7.Yongchang Xu#, Jie Yang#, Weihui Li#, Shuaijie Song#, Yu Shi#, Lihan Wu , Jingdu Sun, Mengyun Hou, Jinzi Wang, Xu Jia, Huimin Zhang, Man Huang, Ting Lu, Jianhua Gan*, Youjun Feng*. Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target. PLoS Pathogens, 2022, 18(7):e1010615. (Top Journal, co-first author)

8.Kun Wang, Yimin Deng, Xujie Cui, Mengli Chen, Yanzhe Ou, Dangting Li, Minhao Guo, Weihui Li*. PatA Regulates Isoniazid Resistance by Mediating Mycolic Acid Synthesis and Controls Biofilm Formation by Affecting Lipid Synthesis in Mycobacteria. Microbiology Spectrum, 2023, 11(3):e0092823. (Top Journal)

9.Kun Wang#, Xujie Cui#, Xiaocui Ling, Jiarui Chen, Jiachen Zheng, Yuling Xiang, Weihui Li*. D-Xylose Blocks the Broad Negative Regulation of XylR on Lipid Metabolism and Affects Multiple Physiological Characteristics in Mycobacteria. International Journal of Molecular Sciences, 2023, 24(8):7086. (Top Journal)

10.Liang Zhou, Zheng-Guo He and Weihui Li*. AraR, a L-arabinose-responding transcription factor, negatively regulates the isoniazid resistance of M. smegmatis. Biochemistry (Moscow), 2019, 84 (5):540-552.

11.Yi Liu, Jinmei Wu, Weihui Li, Jinquan Li, Heyou Han*, Zhiyong Song*. Responsive metal–organic framework nanocarrier delivery system: An effective solution against bacterial infection. Corordination Chemistry Reviews, 2023,496:215413. (I2021F: 24.83, Top Journal)

12.Yugang Li, Weihui Li, Zhiwei Xie, Hui Xu, Zheng-Guo He*. MpbR, an essential transcriptional factor for Mycobacterium tuberculosis survival in the host, modulates PIM biosynthesis and reduces innate immune responses. Journal of Genetics and Genomics, 2019, 46(12):575-589.

13.Yu Liu#, Zhiwei Xie#, Xiling Zhou, Weihui Li, Hua Zhang* and Zheng-Guo He*. NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages. Communications Biology, 2019, 2:65.

14.Feng Huang, Weihui Li, Hui Xu, Huafeng Qin, Zheng-Guo He*. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. PLoS One, 2019, 14(6):e0218449.

15.Jialing Hu, Hua Zhang, Si Zhou, Weihui Li and Zheng-Guo He*. Characterization of a novel regulatory pathway for the mannitol metabolism and its coordination with the biofilm formation in Mycobacterium smegmatis. Journal of Genetics and Genomics, 2018, 45 (9):477-488.

16.Tao Cui, Weihui Li, Lei Liu, Qiaoyun Huang and Zheng-Guo He*. Uncovering New Pathogen-Host Protein-Protein Interactions by Pairwise Structure Similarity. PLoS One, 2016, 11(1):e0147612.

17.Haiwei Zhang, Long Gao, Jiaoling Zhang, Weihui Li, Min Yang, Hua Zhang, Chunhui Gao and Zheng-Guo He*. A Novel marRAB Operon Contributes to the Rifampicin Resistance in Mycobacterium smegmatis. PLoS One, 2014, 9 (8):e106016.

18.Lei Zhang, Weihui Li and Zheng-Guo He*. DarR, a TetR-like Transcriptional Factor, Is Cyclic Di-AMP-responsive Repressor in Mycobacterium smegmatis. Journal of Biological Chemistry, 2013, 288 (5):3085-3096.

19.Yi Wang#, Tao Cui#, Cong Zhang, Min Yang, Yuanxia Huang, Weihui Li, Lei Zhang, Chunhui Gao, Yang He, Yuqing Li, Feng Huang, Jumei Zeng, Cheng Huang, Qiong Yang, Yuxi Tian, Chunchao Zhao, Huanchun Chen, Hua Zhang and Zheng-Guo He*. A Global Protein-protein Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv. Journal of Proteome Research, 2010, 9 (12):6665-6677.

20.Hui Xu, Zhi Su, Weihui Li, Yimin Deng and Zheng-Guo He*. MmbR, a master transcription regulator that controls fatty acid β-oxidation genes in Mycolicibacterium smegmatis. Environmental Microbiology, 2021, 23(2):1096-1114.

21.Xiaohui Li, Liu Chen, Jingjing Liao, Jiechen Hui, Weihui Li and Zheng-Guo He*. A novel stress-inducible CmtR-ESX3-Zn2+ regulatory pathway essential for survival of Mycobacterium bovis under oxidative stress. Journal of Biological Chemistry, 2020, 295 (50):17083-17099.

22.郭旻皓, 凌小翠, 王坤*, 李伟辉*. 结核分枝杆菌的抗逆性与致病性研究进展. 广西科学, 2023, 30(5):841-854.（特邀专稿）

23.王瑞#, 王坤#, 郑慧霞, 张景馨, 金梅, 李伟辉*. 耻垢分枝杆菌转录因子Ms6174广泛调控功能的鉴定及其调控生物被膜形成的机理研究. 基因组学与应用生物学, 2022, 41(第11-12 期合刊):2144-2155.

24.彭莺祺#, 林洁#, 卢思宇, 谷琬琳, 黎兰娟, 王坤*, 李伟辉*. 转录因子FboR调控耻垢分枝杆菌抗氧化生长的机制研究. 基因组学与应用生物学, 2024:43(1):129-138.

Patent:

1. Li Weihui, Wang Kun, Cui Xujie, Zheng Jiachen, Liu Lu, Suo Zhi. Construction of a novel recombinant BCG vaccine strain and its application, Patent for invention (202310029718.2).

2. Li Weihui, Li Danting, Wang Kun, Cui Xujie, Ou Yanzhe. Identification of a novel reporter gene hbpR and its application, Patent for Invention (202310607050.5).