Professor Li Ru, Ph.D., Ph.D. supervisor

Contact

E-mail: liruonly@163.com

Biography

Obtained a Ph.D. from the Wuhan Institute of Virology, Chinese Academy of Sciences in 2010; has been working at the Department of Biotechnology, School of Life Science and Technology, Guangxi University since 2010. Currently, mainly engaged in research on sugarcane disease resistance and the pathogenic mechanism of sugarcane smut fungus. Principal investigator for 4 projects funded by the National Natural Science Foundation of China and 3 projects funded by the Natural Science Foundation of Guangxi Province; participated in 1 project of the National 973 Program; published more than 20 papers.

Teaching and Research Achievements

Teaches undergraduate courses such as "Molecular Biology" and "Biochemistry"; principal investigator for 3 projects funded by the National Natural Science Foundation of China and 2 projects funded by the Natural Science Foundation of Guangxi Province; participated in 1 project of the National 973 Program; published more than 20 papers.

Major Research Projects

National Natural Science Foundation of China, Relationship between Genome DNA Methylation and Virulence Regulation of Chestnut Blight Fungus, 500,000 RMB, Jan 2013 - Dec 2016, Principal Investigator.

National Natural Science Foundation of China, Mechanism Study of MicroRNA Regulation on Virulence of Chestnut Blight Fungus, 400,000 RMB, Jan 2016 - Dec 2019, Principal Investigator.

National Natural Science Foundation of China, Mechanism Study of Acetylation Modification on Virulence of Chestnut Blight Fungus, 400,000 RMB, Jan 2018 - Dec 2021, Principal Investigator.

National Natural Science Foundation of China, Study on the mechanism of m6A methyltransferase CpIME4 in the growth, development and pathogenesis of chestnut blight, 350,000 RMB, Jan 2022 - Dec 2025, Principal Investigator.

Guangxi Key Research and Development Project, Research and Application of Efficient Prevention and Control Technology of Sugarcane Smut, 1,200,000 RMB, May 2023 - May 2026, Principal Investigator.

Natural Science Foundation of Guangxi Province, Mechanism Study of MicroRNA Regulation on Sexual Conjugation of Sugarcane Smut Fungus, 120,000 RMB, Jul 2018 - Jul 2021, Principal Investigator.

973 Program, Revelation and Regulation Mechanism of Fungal Communication System, 3,000,000 RMB, Jan 2015 - Dec 2019, Major Participant.

Independent Research Project of Guangxi Sugarcane Biology Key Laboratory, Molecular Basis and Regulation Mechanism of Sugarcane Resistance to Smut Disease and Tip Rot Disease, 2,000,000 RMB, Jul 2019 - Dec 2021, Major Participant.

Research Directions

Molecular Basis and Regulation Mechanism of Sugarcane Resistance to Smut Disease.

Pathogenic Mechanism and Host Interaction Mechanism of Plant Pathogenic Fungi (Sugarcane Smut Fungus, Chestnut Blight Fungus).

Representative Papers

(1) Li R*, Chen F, Li S, Yuan L, Zhao L, Tian S, Chen B*. Comparative acetylomic analysis reveals differentially acetylated proteins regulating fungal metabolism in hypovirus-infected chestnut blight fungus. Molecular Plant Pathology. 2023, 24(9): 1126-1138.

(1) Li R, Zhao L, Li S, Chen F, Qiu J, Bai L, Chen B*. The autophagy-related gene CpAtg4 is required for fungal phenotypic traits, stress tolerance, and virulence in Cryphonectria parasitica. Phytopathology. 2022, 112(2): 299-307.

(2) Wang J, Quan R, He X, Fu Q, Tian S, Zhao L, Li S, Shi L, Li R*, Chen B*. Hypovirus infection induces proliferation and perturbs functions of mitochondria in the chestnut blight fungus. Frontiers in Microbiology. 2023, 14:1206603.

(3) Li, Ru; Bai, Shan; He, Yuanyuan; Chen, Qi; Wang, Jinzi; Chen, Baoshan*; Cpvma1, a vacuolar H+-ATPase catalytic subunit of Cryphonectria parasitica, is essential for virulence and hypovirus RNA accumulation, Phytopathology, 2019, 109(8): 1417-1424.

(4) Li, Ru; Zhou, Sisi; Li, Yongbing; Shen, Xiaorui; Wang, Zhiqiang; Chen, Baoshan*; Comparative Methylome Analysis Reveals Perturbation of Host Epigenome in Chestnut Blight Fungus by a Hypovirus., Front Microbiol, 2018, 9: 1026-1026.

(5) Li, Ru; Gu, Jing; Chen, Yuanyuan; Xiao, Chuanle; Wang, Liwei; Zhang, Zhiping; Bi, Lijun; Wei, Hongping; Wang, Xude; Deng, Jiaoyu*; Zhang, Xianen*; CobB regulates Escherichia coli chemotaxis by deacetylating the response regulator CheY, Molecular Microbiology, 2010, 76(5): 1162-1174.

(6) Li, Ru; Chen, Peng; Gu, Jing; Deng, Jiaoyu*; Acetylation reduces the ability of CheY to undergo autophosphorylation, FEMS Microbiol Lett, 2013, 347: 70-76.

(7) Liao, Suhuan#; Li, Ru#; Shi, Liming; Wang, Jinzi; Shang, Jianjie; Zhu, Pingchuan; Chen, Baoshan*; Functional analysis of an S-adenosylhomocysteine hydrolase homolog of chestnut blight fungus, FEMS Microbiol Lett, 2012, 336: 64-72.

(8) Shi, Liming; Li, Ru; Liao, Suhuan; Bai, Lingyun; Lu, Qunfeng; Chen, Baoshan*; Prb1, a subtilisin-like protease, is required for virulence and phenotypical traits in the chestnut blight fungus, FEMS Microbiol Lett, 2014, 359: 26-33.

(9) Chen, Qi; Li, Yongbing; Wang, Jinzi; Li, Ru; Chen, Baoshan*; cpubi4 Is Essential for Development and Virulence in Chestnut Blight Fungus, Frontiers in Microbiology, 2018, 9: 0-1286.

(10) Chen, Peng*; Li, Ru; Zhou, Ruiyang; Comparative phosphoproteomic analysis reveals differentially phosphorylated proteins regulate anther and pollen development in kenaf cytoplasmic male sterility line, Amino Acids, 2018, 50(7): 841-862.

(11) Chen, Peng*; Wei, Fan; Li, Ru; Li, Zeng Qiang; Kashif, Muhammad H; Zhou, Rui Yang; Comparative acetylomic analysis reveals differentially acetylated proteins regulating anther and pollen development in kenaf cytoplasmic male sterility line, Physiologia Plantarum, 2019, 166(4): 960-978.

(12) Chen, Peng*; Shi, Qiqi; Liang, Zhichen; Lu, Hai; Li, Ru; Comparative profile analysis reveals differentially expressed microRNAs regulate anther and pollen development in kenaf cytoplasmic male sterility line, Genome, 2019, 62(7): 455-466.

(13) Li, Ru; Gu, Jing; Chen, Peng; Zhang, Zhiping; Deng, Jiaoyu*; Zhang, Xianen*; Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis, Acta Biochim Biophys Sin, 2011, 43(11): 891-899.

(14)李茹;李洋;李林生;廖素环;白凌云;陈保善*;板栗疫病菌ntl基因的功能研究,基因组学与应用生物学, 2013, 32(4): 420-427.

(15)李林生;周思思;姚颜萍;廖素环;陈保善;李茹*;板栗疫病菌cpomt基因的功能,基因组学与应用生物学, 2017, 36(1): 1-6.

(16)桂磊;李茹;白凌云;何熙谱;林海燕;陈保善*;低毒病毒-板栗疫病菌系统作为抗正链RNA病毒化合物筛选模型的研究,基因组学与应用生物学, 2014, 33(5): 975-981.

(17)阎维巍;李茹;陈保善;高效甘蔗黑穗病菌原生质体的制备,基因组学与应用生物学, 2016, (07): 1750-1755.

(18)李茹;陈鹏*;细菌趋化性信号传导及调节机制研究进展,生物技术通报, 2011, 27(11): 109-113.

(19)张姗姗;张沛然;兰仙软;李茹;黄有总;陈保善*;中蔗系列甘蔗品种的黑穗病抗性鉴定,中国糖料, 2019, 41(4): 37-40.