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发布时间:2017年03月16日 11:45 








1. Property And Purpose Of The Course

The field of virology has matured and grown immensely during this time, but one of the major joys of teaching this subject continues to be the solid foundation it provides in topics running the gamut of the biological sciences. Concepts range from population dynamics and population ecology, through evolutionary biology and theory, to the most fundamental and detailed analyses of the biochemistry and molecular biology of gene expression and biological structures. Thus, teaching virology has been a learning tool for us as much, or more, than it has been for our students.

We hope this textbook can provide students with an understanding of :

How virus and host factors interact and how these interactions lead to disease and/or recovery.

How this knowledge can be applied to the prevention and management of disease.

We hope that by the end of this textbook you will understand the mechanics of virus-host interactions in important viral diseases. We also hope that you will be familiar and comfortable with using the literature in virology to understand and solve virological problems and to evaluate strategies for controlling viral diseases.

Specifically, on completing of the course students should be able to:

Explain basic principles of virus taxonomy, structure, replication and host-virus interactions that lead to disease and recovery

For every common or economically important viral disease of animals.

- Know the most appropriate method of diagnosing the disease in a given situation

- determine the most appropriate samples to collect and the best way to submit them

- interpret the results from diagnostic tests used to identify the virus

-explain to the client how the animal acquired the virus, consequences of the infection, the reasons for the signs observed, prognosis, implications for in-contact animals and people and strategies for preventing the disease in other animals

- explain the pathobiology of the viral disease

- interpret the literature on the efficacy of vaccines used to control the disease

For viral diseases not discussed in detail in the textbook

2. Content

Chapter I Formation and Dvelopment of Vrology (4.5 hours)

Main point:1. The virus definitions. 2. The basic characteristics of the virus.

General understanding:Understanding of the history of virology, as well as the velopment of virus in the medical, industrial and agricultural and biological importance, as well as the study of modern virology main content.

Difficulties:the basic characteristics of viruses

Chapter II The Sructure and Cassification of virus (4.5 hours)

Main point:1. The structure of the virus. 2. The classifying principles of the virus

General understanding:The representatives of various HIV virus as well as their English name

Difficulties:capsid and nucleocapsid, nucleocapsid and envelope, the classification of viruses

Chapter III The culture and Quantitative Methods of virus (3 hours)

Main point:1. the cultured virus on chick embryo medium. 2. Macrophage plaque, TCID50, coagulation experiments

General understanding:study the history of virus cultivation, the cultivation of cells,the culture conditions.

Difficulties:the determination of virus titer

Chapter IV The principle of virus replication (3 hours)

Main point:1. The virus life cycle: adsorption, penetration, shell, biosynthesis, maturation and release. 2. The strategy of Virus genome and replication 3. One step growth curve.

General understanding:The replication process of the representative virus

Difficulties:The strategy of Virus genome and replication

Chapter V The interaction between virus and host (3 hours)

Main point:1. The conditions of virus infection . 2. Virus and the immune system

General understanding:The several clinical manifestations after infection

Difficulties:specific immune and non-specific immune

Chapter VI Some important medical classic case of virus disease (6 hours)

Main point:Some important medically viruses' genetic structure and morphological characteristics ,such as common influenza virus, hepatitis B virus and HIV, such as the.

General understanding:the mechanism of these viruses and the disease control strategies.

Difficulties:the variability of influenza virus.

Chapter VII Some important classic case of plant virus diseases (3 hours)

Main point:some important plant viruses such as tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), cauliflower mosaic virus (CaMV), geminivirus morphology, genetic characteristics and control strategies.

General understanding:the types of plant viruses and virus diseases of plants

Difficulties: the virus's genetic characteristics.

Chapter VIII some important virus diseases of animals classic case (3 hours)

Main point:Important animal viruses' genetic structure such as foot and mouth disease virus, rabies virus, prion.

General derstanding:the type and the harm of animal virus.

Difficulties: the genetic material and the replication principle of prion.

Chapter IX The antiviral drugs and viral vaccines (3 hours)

Main point:live attenuated vaccines, killed vaccines, DNA vaccines, the subunit vaccine.

General derstanding:the commonly used antiviral drugs.

Difficulties:the distinction of DNA vaccine and subunit vaccine.

3. Basic Requirements Of Teaching

English courseware will be used during the whole class teaching, and the couse content will be introduced and exlained by English. The stye of teaching includes instruction, asking questions, interpretation, extra-curricular work, examination, and so on. By those steps of teaching, students are required to master and understand the basic characteristics of the virus, common medical, plant and animal viruses, as well as antiviral strategy research.This course lectures (including self-study and discussion) will ran away with 33 course hours, and 3 hours for the final exam. Assessment methods for examination is a comprehensive way, which includes the achievement of answer, disscusion, report, presentation, and the final examination.

4. Bibliography

[1] Alan J. Cann.Principles of Molecular Virology (four edition).科学出版社.2006.

[2] Baoshan Chen.Virology.Guangxi University.2006.

[3] 谢天恩,胡志红主编,《普通病毒学》,科学出版社,2002年10月。

[4] J.Nicklin, K.Graeme-Cook etc. Instant Notes in Microbiology, p269-330. Springer. 1999.

[5] Edward K. Wagner, Martinez J. Hewlett. Basic Virology (second edition). Blackwell publishing. 2004.

[6] S. J. Flint, L. W. Enquist, V. R. Racaniello etc. Principles of Virology (second edition). ASM PRESS. 2004.

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